This combined lecture and hands-on computer tutorial focuses on the basics of computational biophysics and deals with questions like "How can the particle dynamics of thousands of atoms be described precisely?" or "How does a sequence alignment algorithm work?" No cell could live without the highly specialized macromolecules. Proteins enable virtually all tasks in our bodies, e.g. photosynthesis, motion, signal transmission and information processing, transport, sensor system, and detection. The perfection of proteins had already been highly developed two billion years ago.
The aim of the lecture is to develop a physical understanding of those "nano maschines" by using modern concepts of non-equilibrium thermodynamics and computer simulations on the dynamics on an atomic scale. Moreover, the lecture shows (by means of examples from current research) how computers can be used in modern biophysics, e.g. to simulate the dynamics of biomolecular systems, molecular charge transfer or to calculate or refine a protein structure.
During the exercises, the knowledge presented in the lecture is to practical examples to further deepen and strengthen the understanding. By completing homework sets, which are distributed after each lecture, additional aspects of the addressed topics during the lecture shall be worked out. The homework sets are collected during the corresponding exercises.